Placental PharmacologyCRC Press, 6 maj 1996 - 224 sidor Placenta plays a very significant role in the development of secretory and regulatory functions for the maintenance of pregnancy and in the nutrition of the embryo. It shares many functions of the heart, lung, liver, endocrines, and other organs. In Placental Pharmacology, fourteen expert authors discuss how placenta and its component parts can be used effectively in drug development research and in the study of transfer mechanisms across membranes. This reference begins by describing the use of modern biophysical methods to study placental function and prospects for their application in pharmacological research. The next three chapters deal with placental hemodynamics, use of placental tissues and cells in pharmacological assays, and placental transfer of drugs used in pregnancy. Three more chapters contain up-to-date information on molecular biological aspects of placenta currently receiving lots of attention - phospholipase A2 isozymes, imprinted genes and embryogenesis, and placental growth factors. The final chapter describes the clinically relevant topics of placental metabolism and toxicity of homocysteine in placenta. Easy to understand, thorough, and complete, Placental Pharmacology is the perfect resource for scientists interested in placenta and its uses in drug development and testing. |
Innehåll
Chapter | 1 |
Factors Regulating Placental Hemodynamics | 23 |
Chapter 3 | 47 |
Chapter 4 | 67 |
Acknowledgments 883 | 83 |
Chapter 5 | 89 |
Chapter 6 | 105 |
Chapter 7 | 125 |
Chapter 8 | 161 |
193 | |
Vanliga ord och fraser
activity amino acid anesthesia binding Biochem Biol Biophys blastocyst blood bupivacaine caesarean caesarean section choriocarcinoma chorionic chromosome Clin concentrations culture cystathionine cystathionine B-synthase cytotrophoblast decidual deficiency demonstrated differentiation drugs effects eicosanoid embryo Endocrinol endothelial cells enzymatic enzyme epidermal growth factor expression fetus fibroblasts folate function genetic genomic imprinting gestational tissues Gynecol homocysteine homocysteine levels homocystinuria hormone human placenta hyperhomocysteinemia IGF2 IGFs immunoreactive implantation imprinted genes increased inhibin inhibits insulin insulin-like growth factor interactions intracellular mechanisms membrane Metab metabolism methionine methylation molecular mouse mRNA Nature London neonatal nitric oxide normal Obstet pathway patients peptide perfused Pharmacol phospholipase A2 PLA₂ placental placental development placental growth placental tissue placental transfer plasma homocysteine platelet pregnancy production proliferation prostaglandin protein receptor regulation release remethylation Reprod role secretion specific stimulates studies suggested syncytiotrophoblast transforming growth trophoblast tumor Type II PLA uterine vascular vasoconstrictor VEGF vessels villous vitamin B12 vitro