Jacob's Ladder: The History of the Human GenomeW. W. Norton & Company, 2004 - 272 sidor Jacob's Ladder delivers a remarkably lucid explanation of what the sequencing of the human genome really tells us. Decoding the sequence, evolutionary biologist Henry Gee shows, is just the beginning: seeing the letters and words. The next frontier is in understanding snatches of conversation between genes--how they interact to direct the growth of an organism. Gee takes us into the heart of that conversation, illuminating how genes govern a single egg cell's miraculous transformation into a human being, and how they continue to direct that person's day-by-day development throughout a lifetime. Gee tells the story of what we know about the genome today and what we are likely to discover tomorrow. As our knowledge advances, we will be able to direct with increasing authority the conversations between genes: not only performing medical interventions but also creating whole scripts directing birth, ancestry, and diversity in a brave new world. |
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Birth | 3 |
Ex Ovo Omnia | 20 |
Unfolding | 33 |
Revolution | 48 |
Evolution | 66 |
Monsters | 91 |
Genetics | 104 |
PART TWO | 129 |
Operon | 156 |
Monsters reloaded | 173 |
Scars of evolution | 200 |
My travels history | 227 |
Jacobs ladder | 238 |
Notes | 253 |
265 | |
It has not escaped our notice | 131 |
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amino acids ancestors babies bacteria bacterium bases Bateson behaviour beta-galactosidase biology body breeding experiments called cells century chromosomes colleagues contain created creatures Crick Cuvier Darwin embryo enzyme eukaryote evolution evolutionary evolved example existence explain fertilization formless FOXP2 function genetic material genomic network Geoffroy germ Goethe Harvey homeosis Hox cluster Hox genes human embryo human genome idea individual inheritance insects interactions Jacob and Monod junk DNA kind lac operon lactose lambda lancelets linkage groups living Malpighi Mendel messenger RNA mice microscope million years ago molecules monsters multicellular mutation natural selection nature-philosophy neural notochord offspring operon organisms origin of form pair particles pattern peas phenylalanine plants preformation preformationism produce proteins recombination regulation regulatory genes repressor result scientists segment-polarity segments semen sequence single Spallanzani species sperm strand structure substance theory tissues traits transmutation variation vertebrates viruses Wolff