The Vascular Smooth Muscle Cell: Molecular and Biological Responses to the Extracellular Matrix

Framsida
Elsevier, 24 okt. 1995 - 410 sidor
In the last several years, the development of reagents that recognize smooth muscle-specific proteins has enabled researchers to identify smooth muscle cells (SMC) in tissue undergoing both differentiation and repair. These developments have led to increased research on SMC. The latest volume in the Biology of the Extracellular Matrix Series takes a current and all-encompassing look at this growing area of research. Devoted entirely to the subject of SMC, the book covers a diversity of topics-from SMC architecture and contractility to differentiation and gene expression in development. It also examines the proliferation and replication of SMC and its role in pharmacology and vascular disease. A must for cell, developmental, and molecular biologists, this book also will appeal to cardiologists, pathologists, and biomedical researchers interested in smooth muscle cells.
  • Presents a molecular, genetic, and developmental perspective of the vas smooth muscle cell
  • Overview sections highlight key points of chapters, including the clinical relevance of the research and expectations for future study
  • Appeals to both the basic biologist and to the biomedical researcher of vascular disease
 

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Overview
1
Chapter 2 Smooth Muscle Cell Differentiation during Early Development and during Intimal Thickening Formation in the Ductus Arteriosus
17
Chapter 3 Integrins Cytoskeletal and Extracellular Matrix Proteins in Developing Smooth Muscle Cells of Human Aorta
37
Chapter 4 Relevance of Smooth Muscle Replication and Development to Vascular Disease
81
Chapter 5 Smooth Muscle Gene Expression during Developmental Maturation
141
Molecular Identity of Smooth Muscle Cells Overview
163
Smooth Muscle Cell Function from the Clinical Perspective Overview
267
Epilogue
401
Index
403
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